The number of significant injuries across the NFL continues to grow, leaving fantasy football managers scrambling for solutions on their waiver wires. The injury list grew in Week 6, leading fantasy managers to some interesting places in Week 7.
Below are the injuries that could impact fantasy in Week 7. Check this article daily for updates leading up to the games.
Kyler Murray, QB, Arizona Cardinals
Kyler Murray missed Week 6’s game against the Indianapolis Colts due to a foot sprain. There is a chance that Murray misses Week 7’s game as well, especially since the team has a bye week in Week 8. Murray was a limited participant on Wednesday, which is a positive step towards him returning to the field.
If Murray is held out again, Jacoby Brissett will make his second start against the Green Bay Packers.
J.J. McCarthy, QB, Minnesota Vikings
J.J. McCarthy has been out until Week 2 thanks to a high-ankle sprain. The hope for the Vikings was that McCarthy would be prepared to return to the starting lineup after the team’s Week 6 bye. Reports suggested that McCarthy could practice during the bye, but his ankle still was not 100% healthy.
McCarthy did log a limited practice on Wednesday, although he did acknowledge that the doctor had suggested his injury was a six-week ordeal once he was injured.
Biggest takeaway from J.J. McCarthy’s presser is that he acknowledges his right ankle is not 100% yet. He also said he received a recovery timeframe via second opinions of up to 6 weeks. Not great signs for him playing this week.
— Kevin Seifert (@SeifertESPN) October 15, 2025
Head coach Kevin O’Connell has stated that the team will need to see a whole week of practice from McCarthy to get him back on the field. If that doesn’t happen in Week 7, then Carson Wentz will be the starting quarterback against the Philadelphia Eagles again.
Brock Purdy, QB, San Francisco 49ers
Brock Purdy suffered toe and shoulder injuries in Week 1 that kept him out of the lineup for two games. Purdy returned to the field in Week 4, but reaggravated the toe injury. That took him off the field again in Weeks 5 and 6.
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Reports before Week 6’s game against the Buccaneers indicated that Purdy was making significant progress and had a chance to return in Week 7. Mac Jones would be under center again if Purdy hadn’t made the necessary strides to get back onto the field.
Bucky Irving, RB, Tampa Bay Buccaneers
Head coach Todd Bowles has said that Bucky Irving is “not in play” to return to the starting lineup in Week 7. Irving is set to miss his third game of the season.
Rachaad White (78.9% snap share) has dominated the backfield over the last two weeks, and that should continue in Week 7.
Alvin Kamara, RB, New Orleans Saints
Alvin Kamara did not practice on Wednesday due to an ankle injury. This is likely the same injury that occurred during last week’s practice for Kamara.
Kamara saw his usual workload during Sunday’s game, so this seems like more of an opportunity to rest him than a development with his injury. Fantasy managers with Kamara may want to check their waiver wire for Kendre Miller so they have his direct backup.
Chuba Hubbard, RB, Carolina Panthers
Chuba Hubbard has missed the Panthers’ last two games recovering from a lingering calf injury. During that time, Rico Dowdle has led the NFL in rushing (389 yards) and posted back-to-back weeks with 30+ fantasy points per game.
Hubbard is expected to return in Week 7, but his role will likely look different. Dowdle has earned more opportunities. Both players will likely have future fantasy appeal.
CeeDee Lamb, WR, Dallas Cowboys
The Cowboys decided to keep CeeDee Lamb off the injured reserve after he suffered a high-ankle sprain in Week 3 against the Chicago Bears. Lamb has missed three games so far and has a chance to return in Week 7. The veteran receiver had an excellent first step, logging a limited practice on Wednesday.
CeeDee Lamb will practice today
— Jon Machota (@jonmachota) October 15, 2025
In his absence, George Pickens and Jake Ferguson have been the focal points of the passing attack, but Ryan Flournoy (15 targets, nine receptions, and 144 receiving yards in the last two games) has been fantasy-relevant. That would end when Lamb returns to the lineup.
Garrett Wilson, WR, New York Jets
The Jets offense has struggled throughout the season, but Garrett Wilson has been a solid fantasy wide receiver thanks to garbage-time production (16.6 PPR points per game, WR10). Unfortunately, Wilson suffered a knee injury during Week 6’s loss to the Denver Broncos that will cost him a couple of weeks. He did not participate in practice on Wednesday (10/15).
Outside of Wilson, there isn’t much to be excited about in the Jets’ passing attack. Rookie tight end Mason Taylor is second on the team in targets (29). Wide receiver Josh Reynolds was the team’s leading receiver against the Broncos with just three receptions for 25 yards, but he is also nursing a hip injury.
Puka Nacua, WR, Los Angeles Rams
Puka Nacua suffered an ankle injury in the Rams’ Week 6 win against the Baltimore Ravens that took him out of the game. Nacua was able to return, but was clearly limited. Initial reports suggest that the veteran receiver is considered a “long shot” to suit up in Week 7. He did not practice on Wednesday.
Davante Adams is the big winner in the passing attack, but players like Jordan Whittington and Tutu Atwell (if healthy) would see much bigger roles in his absence.
Marvin Harrison Jr., WR, Arizona Cardinals
Marvin Harrison Jr. suffered a concussion in Week 6’s loss to the Indianapolis Colts. It is the second concussion that Harrison has suffered in his two NFL seasons.
Harrison will need to go through the concussion protocol to have a chance of playing in Week 7. It was a good sign that he was considered a limited participant in Wednesday’s team walkthrough.
Typically, concussions will result in at least one game missed. If Harrison cannot suit up, Michael Wilson and Zay Jones have WR3/FLEX appeal against the Green Bay Packers.
Emeka Egbuka, WR, Tampa Bay Buccaneers
Rookie sensation Emeka Egbuka injured his hamstring in Tampa Bay’s Week 6 victory over the San Francisco 49ers. The rookie has seemingly avoided a significant injury, but will still miss time.
From @GMFB: The #Chiefs get WR Rashee Rice back, the #Rams may be without Puka Nacua this week, while the #Bucs likely won’t have WR Emeka Egbuka vs the #Lions. pic.twitter.com/Cf4uPNaLgM
— Ian Rapoport (@RapSheet) October 15, 2025
The Buccaneers’ expansive receiver room is decimated by injury. Veteran Sterling Shepard and rookie Tez Johnson are the most likely options to emerge in the passing attack if Egbuka, Mike Evans, and Chris Godwin cannot play against Detroit.
Terry McLaurin, WR, Washington Commanders
Terry McLaurin has missed three straight games with a quad injury. The veteran receiver has a chance to return in Week 7 and is expected to return to practice this week.
Terry McLaurin will practice this week, today is a jog through and tomorrow will be full speed.
— JP Finlay (@JPFinlayNBCS) October 15, 2025
Wednesday’s practice is a walkthrough, so fantasy managers will want to monitor his status closely on Thursday and Friday. McLaurin’s return would negatively impact the roles of players like Chris Moore, Jaylin Lane, and Luke McCaffrey.
Mike Evans, WR, Tampa Bay Buccaneers
Mike Evans has not played since Week 3 due to a strained hamstring. He is expected to return to practice before the Week 7 game against the Detroit Lions.
Evans’ return could not come at a better time for the Buccaneers, who are expected to be without Emeka Egbuka and Chris Godwin in Week 7. Evans would become the focal point of the passing attack if he can get cleared this week.
Ricky Pearsall, WR, San Francisco 49ers
Ricky Pearsall missed Week 6’s game with a knee injury. The injury was not considered significant when it happened, but it kept the second-year receiver off the field for two weeks. There is optimism that he will return to the lineup in Week 7, but a DNP on Wednesday is not a great sign.
If Pearsall cannot return, Jauan Jennings and Kendrick Bourne would be the biggest winners at wide receiver.
DJ Moore, WR, Chicago Bears
DJ Moore was surprisingly hospitalized after the Bears’ win over the Washington Commanders in Week 6. The initial report was that Moore suffered a groin injury during the game that required more observation.
Moore was released from the hospital and returned to Chicago by Tuesday, but his status in Week 7 is up in the air. If Moore is out, rookie Luther Burden III would see more time in the offense after having a strong game against the Commanders.
Deebo Samuel, WR, Washington Commanders
Deebo Samuel logged a DNP on Wednesday due to a heel injury. Samuel was listed on the injury report all last week with a heel injury, but ultimately logged a similar workload (72.3% snap share) on Monday night.
Josh Downs, WR, Indianapolis Colts
Josh Downs was an unexpected name on the Colts’ injury report. He logged a did not practice (DNP) status on Wednesday due to a concussion. This suggests that Downs is in the concussion protocol, which seriously doubts his Week 7 status.
Chris Godwin, WR, Tampa Bay Buccaneers
Buccaneers’ head coach Todd Bowles also stated that Chris Godwin was “not in play” for Tampa Bay’s Week 7 game against the Detroit Lions. Godwin suffered a fibula injury in his second game of the 2024 season.
Quentin Johnston, WR, Los Angeles Chargers
Quentin Johnston missed Week 6’s game against the Miami Dolphins due to a hamstring injury. The injury is not expected to be a long-term issue, and he can return to the field in Week 7. Johnston participated in Wednesday’s practice, supporting that idea.
Rookie Tre Harris had an expanded role on offense with Johnston off the field. Ladd McConkey (seven receptions for 100 yards and a touchdown) and Oronde Gadsden II (seven for 68 yards) were the biggest winners in the team’s passing attack with Johnston on the sideline.
Darnell Mooney, WR, Atlanta Falcons
Darnell Mooney suffered a hamstring injury in Week 4, but there was hope he wouldn’t miss any additional time due to Atlanta’s Week 5 bye week. Unfortunately, Mooney was out of Week 6’s game against the Buffalo Bills. He was a limited participant in practice on Wednesday (10/15).
Mooney will hopefully return to the field in Week 7, but his practice status must be monitored throughout the week. With Mooney out, Drake London earned a 50% target share against Buffalo. Casey Washington (two targets) was the only other wide receiver to attain a target.
Jalen Coker, WR, Carolina Panthers
Jalen Coker’s practice window was opened during Week 6, but the team ultimately decided not to activate him against the Dallas Cowboys. Coker was logging full practices by the end of the week, meaning his 2025 debut may happen in the team’s Week 7 game against the New York Jets.
Coker logged a limited practice on Wednesday, with head coach Dave Canales mentioning how great he looked. Things are moving in a positive direction.
Brock Bowers, TE, Las Vegas Raiders
Brock Bowers has missed the last two games for the Raiders with a lingering knee injury. There is a chance he could return in Week 7 against the Chiefs, but the Raiders can give him another week of rest with a Week 8 bye on the horizon.
If Bowers is ultimately ruled out, Michael Mayer will continue to operate as the team’s starting tight end. Things seem to be trending that direction after Bowers logged a DNP on Wednesday.
George Kittle, TE, San Francisco 49ers
George Kittle was eligible to return from the injured reserve in Week 6 after suffering a hamstring injury in the 49ers’ opening game. A strong start allowed the 49ers to give their veteran tight end one more week to completely heal instead of rushing him back to the field.
Kittle logged a limited practice on Wednesday, which suggests his practice window from the injured reserve has been opened. That is a great first step toward Kittle returning to the field.
David Njoku, TE, Cleveland Browns
Thanks to a knee injury, David Njoku missed time during Week 6’s game against the Pittsburgh Steelers. After the game, we learned that Njoku suffered a hyperextended knee. The injury is not considered severe, but it could cause him to miss a short period.
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Rookie tight end Harold Fannin Jr. had his best game of the season in Week 6 (10 targets, seven receptions, 81 receiving yards) with Njoku off the field. He would be a top-12 tight end if Njoku cannot play.
Njoku did not practice on Wednesday (Oct. 15).
