For the first time since 1979, Columbia will host a game between a pair of top-15 teams in the nation. The eighth-ranked Alabama Crimson Tide heads to Missouri to take on the 14th-ranked Tigers. These are two of the best teams in the country on both sides of the ball, and this could be a key matchup in determining which of these teams makes it to the College Football Playoff’s field of twelve.
This comprehensive Alabama vs. Missouri prediction features exclusive PFSN player and team grades alongside detailed analysis of both programs’ current form and capabilities.
Alabama vs. Missouri Game Details
- Date: Saturday, Oct. 11, 2025
- Game time: 12 p.m. ET
- Location: Memorial Stadium, Columbia, Mo.
- Predicted weather at kick: 71 degrees, partly cloudy
- How to watch: ABC
Alabama vs. Missouri Head-to-Head Record
Alabama and the Missouri Tigers have met just eight times since their first matchup in 1968. Missouri won the first two meetings, and Alabama has won the most recent six. Missouri joined the SEC in 2012, and the games have become a bit more frequent since then, with five matchups occurring between 2012 and 2024. I expect them to lock horns more often now that they share a conference.
Alabama vs. Missouri Grades
Below are the PFSN team and positional grades for the highest-ranked players set to be featured in Alabama vs. Missouri.
PFSN College OFFi
- Alabama (90.01, A-)
- Missouri (86.8, B)
PFSN College DEFi
- Alabama (84.47, B)
- Missouri (89.76, B+)
PFSN College OL
- Alabama (85.7, B)
- Missouri (86.3, B)
PFSN College QBi
- Ty Simpson, Alabama (89.1, B+)
- Beau Pribula, Missouri (76, C)
PFSN College RBi
- Kevin Riley, Alabama (N/A)
- Ahmad Hardy, Missouri (82.72, C)
PFSN College WRi
- Ryan Williams, Alabama (81.4, B-)
- Kevin Coleman Jr., Missouri (83.4, B)
PFSN College TEi
- Josh Cuevas, Alabama (80.08, B-)
- Brett Norfleet, Missouri (78.18, C+)
PFSN College EDGEi
- LT Overton, Alabama (78.3, C+)
- Zion Young, Missouri (87.8, B+)
PFSN College DTi
- James Smith, Alabama (78.07, C+)
- Chris McLellan, Missouri (72.92, C-)
PFSN College LBi
- Justin Jefferson, Alabama (74.54, C)
- Khalil Jacobs, Missouri (67.4, D+)
PFSN College CBi
- Zabien Brown, Alabama (81.4, B-)
- Stephen Hall, Missouri (77.6, C+)
PFSN College SAFi
- Keon Sabb, Alabama (95.27, A)
- Santana Banner, Missouri (79.4, C+)
Alabama vs. Missouri Prediction
The Alabama Crimson Tide is looking to avoid riding too high into Columbia, as the Missouri Tigers will be ready for them and hungry for the biggest game on their campus in a very long time.
Alabama is coming off a win in Athens over a Georgia team that was favored to beat them, but winning big games is nothing new to the Crimson Tide. Missouri played very well in its last SEC game, a 29-20 win over South Carolina, in which it showed great determination in coming back from a halftime deficit.
The Missouri defense is built on the heels of two stellar edge rushers. Still, outside of that, the defense isn’t daunting or much of a threat to Alabama’s incredible passing offense, which has seen Ty Simpson get better with each passing week.
This is @AlabamaFTBL! #RollTide pic.twitter.com/hrw6dF9v2I
— Jared Shadix (@CrimsonPatriot7) October 7, 2025
Look for Missouri to come out with a ton of energy and play a clean game, but then for the Alabama team to stand tall and answer every punch as it is thrown. Missouri has a high-octane offense, but Alabama’s overall execution and adjustments are likely to determine the outcome.
Prediction: Alabama 37, Missouri 27
