Serie A official Week 4 line-ups

September 21, 2025

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AMSTERDAM, NETHERLANDS – SEPTEMBER 17: Marcus Thuram of Internazionale celebrates scoring his team’s second goal with team mates during the UEFA Champions League 2025/26 League Phase MD1 match between AFC Ajax and FC Internazionale Milano at Johan Cruijff Arena on September 17, 2025 in Amsterdam, Netherlands. (Photo by Dean Mouhtaropoulos/Getty Images)

Inter need to get their Serie A season back on track, but Francesco Pio Esposito again partners Marcus Thuram upfront against Domenico Berardi’s Sassuolo.

It kicks off at San Siro at 19.45 UK time (18.45 GMT).

You can follow all the build-up and action as it happens from today’s five Serie A games on the Liveblog.

TURIN, ITALY - SEPTEMBER 13: Hakan Calhanoglu of Internazionale celebrates scoring his team's first goal during the Serie A match between Juventus FC and FC Internazionale at on September 13, 2025 in Turin, Italy. (Photo by Valerio Pennicino/Getty Images) — TURIN, ITALY – SEPTEMBER 13: Hakan Calhanoglu of Internazionale celebrates scoring his team’s first goal during the Serie A match between Juventus FC and FC Internazionale at on September 13, 2025 in Turin, Italy. (Photo by Valerio Pennicino/Getty Images)

The Nerazzurri were in crisis after back-to-back Serie A defeats to Udinese and rivals Juventus, but there was a significant step forward in the midweek Champions League victory away to Ajax.

Now they need to bring some of that European form to domestic football, but Lautaro Martinez is still not fully fit after missing the Amsterdam clash with a back injury.

Young striker Esposito is therefore confirmed upfront with brace hero Thuram.

There is rotation elsewhere, with the return of Francesco Acerbi, Carlos Augusto and Petar Sucic, but also goalkeeper Josep Martinez giving Yann Sommer a rest.

REGGIO NELL'EMILIA, ITALY - APRIL 21: Inter linked Domenico Berardi of US Sassuolo during the Serie A TIM match between US Sassuolo and US Lecce at Mapei Stadium - Citta' del Tricolore on April 21, 2024 in Reggio nell'Emilia, Italy.(Photo by Alessandro Sabattini/Getty Images) — REGGIO NELL’EMILIA, ITALY – APRIL 21: Inter linked Domenico Berardi of US Sassuolo during the Serie A TIM match between US Sassuolo and US Lecce at Mapei Stadium – Citta’ del Tricolore on April 21, 2024 in Reggio nell’Emilia, Italy.(Photo by Alessandro Sabattini/Getty Images)

Sassuolo had a rough start to the season with defeats to Napoli and Cremonese, but got themselves off the mark with a 1-0 victory against Lazio.

Yeferson Paz and Laurs Skjellerup are on the treatment table, but veteran Berardi starts in the trident attack with Armand Laurienté and former Inter youth player Andrea Pinamonti.

Nemanja Matic and ex-Milan midfielder Aster Vranckx also start for the side that won the Serie B title last season.